Publications
Vn96* Peptide, a novel tool for convenient and efficient enrichment of urinary eMVs containing informative prostate cancer protein and mRNA biomarkers
- Details
- Conference Paper
Early detection of prostate cancer (PCa) currently relies on serum PSA and digital rectal examination (DRE), both of which lack diagnostic specificity and prognostic value. Hence, there is a great demand for new and better PCa biomarkers. Urinary extracellular microvesicles (eMVs) have valuable potential as a novel, noninvasive
and enriched source of biomarkers. Conventional means of eMV isolation involve time-consuming ultracentrifugation (UCF) or expensive commercial methods. Our group has developed a fast, simple and cost-effective method for enrichment of eMVs from urine using a peptide (Vn96) with affinity for heat shock proteins.